in the united states the 5-year survival rate for cancer overall is currently health

In addition, colon cancer is characterized by rapid progression and metastasis that results in a variable prognosis for patients. The heterogeneity of colon cancer contributes to variable diagnosis, which results in a low 5-year survival rate for patients with advance-stage metastatic disease and a high recurrence rate. It is estimated that 2.2 million new cases of colorectal cancer will occur by 2030, as well as 1.1 million deaths from colorectal cancer. Over 1.9 million incidences and 0.9 million deaths occurred worldwide in 2020. Globally, colon cancer is one of the most common digestive cancers, and its incidence is projected to increase. Also, CXCL14 was identified as an underlying therapeutic target for colon cancer. Our result could improve the understanding of the liver metastasis process in colon cancer. Furthermore, we found that the patients with low CXCL14 expression might be more sensitive to etoposide, rapamycin and sunitinib. Immune infiltration analysis showed that for the patients with high CXCL14 levels, the plasma B cells, CD8 + T cells, neutrophil and NK cells might infiltrate more, in contrast to B cells, monocyte and macrophages. Then, biological enrichment analysis indicated that the CXCL14 is predominantly involved in the activating of the WNT/β/catenin pathway, pancreas beta cells, peroxisome and bile acid metabolism. The result showed that the CXCL14 is a protective factor against colon cancer independent of other clinical parameters like age, gender, clinical stage, and TNM classifications. Further, the clinical role of CXCL14 in colon cancer was also explored. Meanwhile, the biological role of fibroblasts in the colon cancer microenvironment was investigated. Single-cell analysis showed that the CXCL14 was mainly expressed in the fibroblasts. The CXCL14 was selected for further analysis for its most significant P value. Moreover, we identified that the molecules SERPINA3, SERPINA1, MMP3, ALDH1A3, PBK and CXCL14 were the independent factors for patients survival. The biological role of these molecules was identified through the GO and KEGG analysis. In our study, we systematically explored the molecules involved in the liver metastasis process of colon cancer. All the analysis was performed in R software. MethodsĪll the data enrolled in this study were downloaded from two public databases, The Cancer Genome Atlas Program, the TCGA-COAD project and Gene Expression Omnibus, GSE41258 project. The most common cause of death for colon cancer patients is liver metastasis.

In the united states the 5-year survival rate for cancer overall is currently health